Title : Targeting the Deregulated Spliceosome Core Machinery in Cancer Cells Triggers Mtor Blockade and Autophagy Running Title : Spliceosome as a Target for Anticancer Treatment
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چکیده
Title : Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy Running title : Spliceosome as a target for anticancer treatment Authors : Virginie Quidville§, Samar Alsafadi§ Aïcha Goubar, Frédéric Commo, Véronique Scott, Catherine Durieu, Isabelle Girault, Sonia Baconnais, Eric Le Cam, Vladimir Lazar, Suzette Delaloge, Mahasti Saghatchian, Patricia Pautier, Philippe Morice, Philippe Dessen, Stéphan Vagner1,2,3, and Fabrice André1,2,3,
منابع مشابه
Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy.
The spliceosome is a large ribonucleoprotein complex that guides pre-mRNA splicing in eukaryotic cells. Here, we determine whether the spliceosome could constitute an attractive therapeutic target in cancer. Analysis of gene expression arrays from lung, breast, and ovarian cancers datasets revealed that several genes encoding components of the core spliceosome composed of a heteroheptameric Sm ...
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